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- W2362051346 abstract "Objective To evaluate the role of KAI1 gene injection in inhibiting metastasis of pancreat ic cancer in vivo . Methods Heterotopic human pancreatic ade noca rcinoma was successfully established in the groin of BALB/C nude mice by subcuta neous injection of MiaPaCaⅡ pancreatic cancer cells. The tumor-bearing mice we re randomly divided into two groups: day-10 group, where treatment was started from the 10~(th) day of cancer cell inoculation, and day-21 group, where tre atment was started from the 10~(th) day of cancer cell inoculation. 100 μg r ecombinantplasmid pCMV-KAI1, 100 μg pCMV-KAI1-LipofectAMINE(1∶1), or 100 μl saline was directly injected into pancreatic adenocarcinoma at a 7-day inte rval for three times. At day 50, the tumor growth and metastasis were measured. Results In the KAI1 group and KAIl-LipofectAMINE group of day -10 group, the tumor volume inhibitory rate of treatment group and control grou p was 63.79% vs 73.51%, the tumor weight inhibitory rate was 77.12% vs 8 3.26%, the weight of lung was (0.33 ± 0.09)g vs (0.30 ± 0.09)g, the weight o f liver was (1.01 ± 0.27)g vs (0.99 ± 0.21)g, and the lung metastatic nodule num ber was 0.5 ± 0.83 vs 2.33 ± 1.63, respectively. These data were less than those of control group( P 0.05). There was no significant difference between KAI1 group and KAIl-LipofectAMINE g roup ( P 0.05). In 21-day group, ther e was no significant difference in tumor volume, tumor weight, weight of lung, weight of liver and the lung metastatic nodule number between gene therapy group and salin e control group ( P 0.05). Con clusions KAI1 gene directly injected into pancreatic adenocarcinoma pla ys an important role in inhibiting the growth and metastasis of MiaPaCaⅡ pancre atic cancer. The suppressive role of KAI1 gene was closely correlated with the t ime phase of injecting gene into tumor." @default.
- W2362051346 created "2016-06-24" @default.
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- W2362051346 date "2006-01-01" @default.
- W2362051346 modified "2023-09-26" @default.
- W2362051346 title "KAI1 gene inhibits in vivo metastasis of human pancreatic cancer." @default.
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