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- W2362055902 abstract "Aim To study the effect of sodium quercetin-7-sulfate (SQMS) on activity of recombinant human phosphoinositide 3-kinase (PI3-K) p110β catalytic subunit.Methods Recombinant human PI3-K p110β catalytic subunit was expressed by gene engineering.PI3-K activity was assayed by incubating recombinant PI3-K p110β with phosphatidylinositol-4,5-bisphosphate and [γ-~ ~32 P]ATP; the ~ ~32 P-radiolabeled lipids were extracted with chloroform and methanol, and assessed by scintillation counter.Results SQMS showed inhibition on the recombinant p110β catalytic subunit with IC_~50 13.14 μmol·L~-1 .Conclusions SQMS is an inhibitor of PI3-K. The recombinant PI3-K p110β catalytic subunit might be used as a molecular target for simpler target screening more effective inhibitors of PI3-K." @default.
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- W2362055902 date "2005-01-01" @default.
- W2362055902 modified "2023-09-27" @default.
- W2362055902 title "Effect of sodium quercetin-7-sulfate on enzyme activity of recombinant human phosphoinositide 3-kinase p110#beta# catalytic subunit" @default.
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