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- W2362056484 abstract "To determine the neuroprotective effects of seed watermelon polysaccharide on PC12 cells injured by H2O2 and the molecular mechanisms underlying these neuroprotective effects. The cell viability was analyzed by CCK-8 assay,the toxicity model was established by treating PC12 cells with H2O2. The releasing rate of LDH was determined by the color reaction of diaphorase INT. ROS production was determined by DCFH-DA fluorescence. 8-OHd G production was determined by ELISA. Mitochondria membrane potential was determined by JC-1 staining. Caspase-3 activity was determined by caspase-3 catalyze the substrate specificity Ac-DEVD-p NA. Caspase-9 activity was determined by caspase-9 catalyze the substrate specificity Ac-LEHD-p NA. In comparison to control cells,exposure of cells to 500 μmol / L H2O2 for 24 h resulted in approximately 65% cell viability of control( P 0. 01). H2O2 induced significantly the increase of LDH release,intracellular ROS and 8-OHd G( P 0. 01),and the decrease of mitochondrial membrane potential( P 0. 01).H2O2 induced oxidative stress increased caspase-3 and caspase-9 activity( P 0. 01). Compared with H2O2 group,different doses of SWP can significantly improve the change of the index H2O2-induced( P 0. 05). Polysaccharide from seed watermelon had protective effect on PC12 cells injury induced by H2O2 in culture." @default.
- W2362056484 created "2016-06-24" @default.
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- W2362056484 date "2015-01-01" @default.
- W2362056484 modified "2023-09-25" @default.
- W2362056484 title "Protective Effects of Polysaccharide from Seed Watermelon on the Oxidative Damage of PC12 Cells Induced by H_2O_2" @default.
- W2362056484 hasPublicationYear "2015" @default.
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