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- W2362056720 abstract "Objective:To clarify the mechanism of crisis serum' mediated gametocyte infectivity to the mosquito vector Methods:Observing the effects of mouse serum , which was obtained 5 days after P yoelii infection (D5 serum) on gametocyte infectivity by IFA and mosquito live feeds, and the production of IFN γ?TNF α?IL 4 and NO - 2 in the hosts in vivo and in vitro by ELISA and Griess reaction And to investigate the ability of malaria parasitized red blood cell extract (PRBC extract) to induce NO Results:The development of the gametocytes from mice 5 days postinfection into ookinetes were completely inhibited D5 serum was not immediate to inhibit gametocyte development, which was injected intravenously into the mice 3 days after P yoelii infection But 4 h later after injection D5 serum stimulated the increasing IFN γ and NO production and inhibited gametocyte infectivity Moreover, PRBC extract showed the ability to induce NO Conclusion:Infected host serum blocks transmission of P yoelii via a nitric oxide dependent mechanism" @default.
- W2362056720 created "2016-06-24" @default.
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- W2362056720 date "2001-01-01" @default.
- W2362056720 modified "2023-09-23" @default.
- W2362056720 title "The study of the effective mechanism of infected host serum on the infectivity of gametocytes of Plasmodium yoelii (P.yoelii)" @default.
- W2362056720 hasPublicationYear "2001" @default.
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