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- W2362057493 abstract "Objective To evaluate the barrier effect of the different compositions of polysaccharide carrier materials on the drug release of the upper gastrointestinal tract. Methods Polysaccharide carrier material free films were prepared and the effects of the Prescription form and permeable medium on the swelling and permeability of free films were investigated. Results When the pectin∶chitosan∶calcium ratio of the free film was 40∶1∶40 in the pH1.0 dilute hydrochloric acid at 37℃,the free film showed its minimum swelling degree,and its maximum swelling degree was 1.25. The pectin-Ca-chitosan(40∶1∶40) film showed its minimum permeability,with its permeability coefficient as 1.8737×10-(5cm/s)in the pH7.4 buffer at 37℃ in the absence of enzyme. The permeability coefficient was bigger in the pH7.4 buffer at 37℃ in the presence of enzyme than that in the absence of enzyme. Conclusion The pectin-Ca-chitosan film can increase the barrier effect of the drug release of the upper gastrointestinal tract,which is conducive to profit the colon-specific drug delivery." @default.
- W2362057493 created "2016-06-24" @default.
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- W2362057493 date "2010-01-01" @default.
- W2362057493 modified "2023-09-24" @default.
- W2362057493 title "Preparation and Properties of Pectin-calcium-chitosan of Free Films" @default.
- W2362057493 hasPublicationYear "2010" @default.
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