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- W2362082490 abstract "Objective To explore the effect of SjC23 DNA vaccine on regulation of hepatic granuloma of schistosomiasis japonica and assess its potential to be as an anti-pathology vaccine. Methods Thirty Songjiang native pigs were divided into A、B、C groups. In group A (SjC23 group), each pig was immunized (i. m.) with 500μg SjC23 DNA in both buttocks. In group B(SjC23+IL-12 group), each pig was immunized with 500μg of SjC23 plasmid DNA and the mixture of 500μg of pcDNA-P35 and 500μg of pcDNA P40 plasmid DNA by i.m.. Each pig was immunized (i.m.) with 500μg of pcDNA3.1 as control in group C.Immunized for 3 times at week O, 3, 6. At day 30 after last immunization each pig was challenged with 600 cercarae of Si. 45 days later the pigs were sacrificed. 1.5cm~3 of liver piece was cut from each leaf of the liver. The paraffin sec- tions were prepared by routine procedure. The egg granulomas of liver in each section were investigated. The square measure and diameter of each granuloma were measured and analyzed with NYD-1000 Image Analysis System. The average square measure size and diameter of granuloma were calculated for each group and com- pared between groups. Results Compared with control group, the average square measures of SjC23 group and SjC23+IL-12 group were reduced by 48.57% and 44.37% respectively, the diameters were diminished by 27.56% and 22.78% respectively. Conclusion SjC23 DNA vaccine could be down regulation of liver granulo- ma of Schistosomiasis japonica; it could be potential as an anti-pathology vaccine candidate of schistosomiasis." @default.
- W2362082490 created "2016-06-24" @default.
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- W2362082490 date "2003-01-01" @default.
- W2362082490 modified "2023-09-27" @default.
- W2362082490 title "Effect on anti-pathology for 23kDa membrane Protein DNA vaccine of schistosoma Japonicum" @default.
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