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- W2362095735 abstract "Objective: To investigate the influence of a-keto acid on the cardiac function and serum inflammatory factor in patients undergoing maintenance hemodialysis.Methods:A total of 80 patients with chronic renal failure that regularly underwent MHD were randomly divided into a-keto acid group and non-a-keto acid group,40 healthy volunteers were also enrolled in this study.Plasma concentrations of IL-6,CRP,TNF-α,MMP-2,and MMP-9 were measured by enzyme linked immunoassay(ELISA).Cardiac structure parameters including LADs,LVEDd,IVSTd,LVPWTd,LAI,IVMI,RWT,LVEF,FS,E/A were also detected before the treatment and 6 months after the treatment.Results:The plasma level of MMP-2,IL-6,TNF-α,CRP were significant higher in chronic renal failure patients than that in healthy volunteers(P0.05),but MMP-9 was also significant lower(P0.05).The plasma level of MMP-2,IL-6,CRP,TNF-α were decreased and MMP-9 was increased in a-keto acid group after 6 months of treatment compared with non-a-keto acid group(P0.05).No significant difference in RWT was observed between the two groups(P0.05).LVEF,FS,E/A value of the a-keto acid group was significantly increased than the non-a-keto acid group(P0.05).Conclusions:Application of a-keto acid therapy can decrease the plasma IL-6、TNF-a、CRP and MMP2 level,while increase MMP2 level.Besides,it also improve renal function,cardiac structure,thus can prevent cardiovascular events and improve life quality and long-term survival rate for patients with chronic renal failure." @default.
- W2362095735 created "2016-06-24" @default.
- W2362095735 creator A5018709181 @default.
- W2362095735 date "2013-01-01" @default.
- W2362095735 modified "2023-09-24" @default.
- W2362095735 title "Influence of a-keto acid on the cardiac function and serum inflammatory factor in patients undergoing maintenance hemodialysis" @default.
- W2362095735 hasPublicationYear "2013" @default.
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