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- W2362095909 abstract "The purpose of this study was to define the renal effect of enalapril in patients with essential hypertension with mild to moderate renal dysfunction. 27 patients, aged 58±8 years,were divided into three groups:(1)azotemia stage(n=8):creatinine clearance rate (Ccr):10-50ml/min and/or serum creatinine(Scr):200-445μmol/L.(2)compensation stage(n=9):Ccr:50-80 ml/min and/or Scr 120-200 μmol/L.(3)normal renal function stage (n=10).The following parameters were measured:renal plasma flow (RPF)assesed by paraminohippurate clearance rate (HPLC method);glomerular filtration rate(GFR) assesed by sodium sulfosulfate clearance rate with microcolorimetry; urinary microprotein excretion,including albumin(UMAE/Cr),transferin (UMTE/Cr), IgG(UMGE/Cr),retinol binding protein(RBP)and N-acetyl-β-D-glucosaminide,(NAG)by ELISA method,before and after receiving enalapril monotherapy. Compared with pretreatment, GFR and RPF were improved significantly in group 2(P0.05,P0.01,respectively), RPF was improved in group 3(P0.05)and renal vascular resistence (RVR) was decreased in group 2 and group 3(P0.05, both).UMAE/Cr and UMGE/Cr decreased significantly in group 3(P0.05, both) and UMAE/Cr, UMTE/Cr and NAG/Cr decreased significantly in group 1(P0.05,all).In all groups,RBP/Cr tended to decrease after rceiving enalapril.One patient in group 1 developed hyperkalimia(7.8 mmol/L) but returned to normal after discontinuation of enalapril.Thus,in hypertensive patients with mild to moderate renal dysfunction,treatment with enalapril may improve renal function. However,a smaller dose(10 mg/day)should be given with repeated assay of serum potasium and urinary protein excretion especially in patients with more ad vanced renal dysfunction." @default.
- W2362095909 created "2016-06-24" @default.
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- W2362095909 date "1996-01-01" @default.
- W2362095909 modified "2023-09-23" @default.
- W2362095909 title "EFFECT OF ENALAPRIL IN PATIENTS WITH ESSENTIAL HYPERTENSION ASSOCIATED WITH MILD TO MODERATE RENAL DYSFUNCTION" @default.
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