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- W2362098769 abstract "Objectives: To explore the effects of rosiglitazone on serum levels of transforming growth factor-β1(TGF-β1) and interleukin-1β(IL-1β) in patients with type 2 diabetes mellitus(T2DM) and acute coronary syndrome(ACS).Methods: 116 patients with T2DM and ACS were randomly divided into rosiglitazone group(n=58) and control group(n=58).Fasting plasma glucose(FPG),plasma lipids,serum TGF-β1 and IL-1β of the patients were measured at baseline and after 4-month treatment.Results: At baseline,FPG,plasma lipids,serum TGF-β1 and IL-1β were similar between the two groups(all P0.05).After 4-month treatment,serum IL-1β levels in the two groups were significantly decreased(P0.01) while serum TGF-β1 levels were significantly increased(P0.05).Moreover,the changes in serum TGF-β1 and IL-1β were enhanced(both P0.05) in rosiglitazone group compared with control group.Additionally,serum TGF-β1 and IL-1β levels after treatment were similar between the two groups.Conclusion: Rosiglitazone may reg-ulate the releases of inflammatory mediator and anti-inflammatory factor and consequently ameliorate atherosclerosis in patients with T2DM and ACS." @default.
- W2362098769 created "2016-06-24" @default.
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- W2362098769 date "2011-01-01" @default.
- W2362098769 modified "2023-09-24" @default.
- W2362098769 title "Effects of Rosiglitazone on Serum Levels of TGF-β1 and IL-1β in Patients with Type 2 Diabetes Mellitus and Acute Coronary Syndrome" @default.
- W2362098769 hasPublicationYear "2011" @default.
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