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- W2362098826 abstract "Objective To explore the changes and the significance of serum levels of 8-iso-prostaglandin F2α( 8-isoPGF2α),total antioxidant capacity( T-AOC) and macrophage-derived chemokine( MDC) in stage Ⅰ silicosis patients.Methods The levels of serum 8-iso-PGF2α in fifty-eight stage Ⅰ silicosis patients( silicosis group),35 healthy miners( dust-contacted group) and 33 cases of healthy non underground workers( control group) were detected by enzyme-linked immunosorbent assays,meanwhile,the MDC and T-AOC levels were also detected by Luminex fluorescence technique and chemistry colorimentric method,respectively. Results Comparing with control group,the serum T-AOC level in dust-contacted group and silicosis group was significantly increased,the serum MDC level in dust-contacted group was significantly reduced( all P0. 01); the serum levels of 8-iso-PGF2α and T-AOC were significantly lower and the serum levels of MDC in silicosis group was significantly higher than those of dust-contacted group( P0. 05,P0. 01) and there was a negative correlation between T-AOC and MDC in stage Ⅰ silicosis patients( r =- 0. 247,P 0. 05); additionally,serum levels of T-AOC in silicosis with COPD was significantly higher than that of simple silicosis( P0. 05); the levels of 8-iso-PGF2α in drinking silicosis patients were significantly lower than that of non-drinking patients( P0. 05). Conclusion The results suggested that in stage Ⅰ silicosis patients,serum levels of 8-iso-PGF2α、T-AOC and MDC were abnormal and related to the development of silicosis; and drinking might affect the serum level of 8-iso-PGF2α in silicosis patients." @default.
- W2362098826 created "2016-06-24" @default.
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- W2362098826 date "2015-01-01" @default.
- W2362098826 modified "2023-09-23" @default.
- W2362098826 title "Serum levels of 8-iso-PGF2α,T-AOC and MDC in stage I silicosis patients" @default.
- W2362098826 hasPublicationYear "2015" @default.
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