Matches in SemOpenAlex for { <https://semopenalex.org/work/W2362103667> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2362103667 abstract "It has been widely accepted that T cell-mediated antitumor immunity requires at least two signals from T cell receptor and costimulatory molecules. The co-signal provided by co-inhibitory or co-stimulatory molecules determines the final outcome of the immune response mediated by T cell receptor signalling. Recently, great clinical successes have been achieved in drugs targeting co-inhibitory signaling such as CTLA-4 and PD-1, which makes immunotherapy become the most notable research area and receive the 2013's Breakthrough of Year award made by the journal Science. Cancer immunotherapy is expected to become a mainstay treatment for cancer in addition to surgery, radiation, chemotherapy, and targeted therapy. In this review, the most important co-inhibitory(CTLA4, PD-1/PD-L1) and co-stimulatory drug targets(CD137), their mechanisms of regulating cellular immune responses, as well as the recent development and applications of the targeted agents in cancer therapy were discussed." @default.
- W2362103667 created "2016-06-24" @default.
- W2362103667 creator A5041421385 @default.
- W2362103667 date "2015-01-01" @default.
- W2362103667 modified "2023-09-23" @default.
- W2362103667 title "Advances in Research on Cancer Immunotherapy Targeting T Cell Co-signalling" @default.
- W2362103667 hasPublicationYear "2015" @default.
- W2362103667 type Work @default.
- W2362103667 sameAs 2362103667 @default.
- W2362103667 citedByCount "0" @default.
- W2362103667 crossrefType "journal-article" @default.
- W2362103667 hasAuthorship W2362103667A5041421385 @default.
- W2362103667 hasConcept C121608353 @default.
- W2362103667 hasConcept C126322002 @default.
- W2362103667 hasConcept C203014093 @default.
- W2362103667 hasConcept C2776090121 @default.
- W2362103667 hasConcept C2777701055 @default.
- W2362103667 hasConcept C2780249625 @default.
- W2362103667 hasConcept C2780674031 @default.
- W2362103667 hasConcept C39743133 @default.
- W2362103667 hasConcept C502942594 @default.
- W2362103667 hasConcept C71924100 @default.
- W2362103667 hasConcept C86803240 @default.
- W2362103667 hasConcept C8891405 @default.
- W2362103667 hasConcept C95444343 @default.
- W2362103667 hasConceptScore W2362103667C121608353 @default.
- W2362103667 hasConceptScore W2362103667C126322002 @default.
- W2362103667 hasConceptScore W2362103667C203014093 @default.
- W2362103667 hasConceptScore W2362103667C2776090121 @default.
- W2362103667 hasConceptScore W2362103667C2777701055 @default.
- W2362103667 hasConceptScore W2362103667C2780249625 @default.
- W2362103667 hasConceptScore W2362103667C2780674031 @default.
- W2362103667 hasConceptScore W2362103667C39743133 @default.
- W2362103667 hasConceptScore W2362103667C502942594 @default.
- W2362103667 hasConceptScore W2362103667C71924100 @default.
- W2362103667 hasConceptScore W2362103667C86803240 @default.
- W2362103667 hasConceptScore W2362103667C8891405 @default.
- W2362103667 hasConceptScore W2362103667C95444343 @default.
- W2362103667 hasLocation W23621036671 @default.
- W2362103667 hasOpenAccess W2362103667 @default.
- W2362103667 hasPrimaryLocation W23621036671 @default.
- W2362103667 hasRelatedWork W1835976867 @default.
- W2362103667 hasRelatedWork W1928807762 @default.
- W2362103667 hasRelatedWork W1939942194 @default.
- W2362103667 hasRelatedWork W2036150991 @default.
- W2362103667 hasRelatedWork W2050941607 @default.
- W2362103667 hasRelatedWork W2081375494 @default.
- W2362103667 hasRelatedWork W2120345471 @default.
- W2362103667 hasRelatedWork W2276522360 @default.
- W2362103667 hasRelatedWork W2345568581 @default.
- W2362103667 hasRelatedWork W2548593828 @default.
- W2362103667 hasRelatedWork W2555713829 @default.
- W2362103667 hasRelatedWork W2769886328 @default.
- W2362103667 hasRelatedWork W2791722947 @default.
- W2362103667 hasRelatedWork W2888555926 @default.
- W2362103667 hasRelatedWork W2890003516 @default.
- W2362103667 hasRelatedWork W2901888715 @default.
- W2362103667 hasRelatedWork W2988641584 @default.
- W2362103667 hasRelatedWork W2994407403 @default.
- W2362103667 hasRelatedWork W3003857191 @default.
- W2362103667 hasRelatedWork W3006201797 @default.
- W2362103667 isParatext "false" @default.
- W2362103667 isRetracted "false" @default.
- W2362103667 magId "2362103667" @default.
- W2362103667 workType "article" @default.