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- W2362104933 abstract "Objective To evaluate the therapeutic effects and inflammatory mediator levels in induced sputum of H1 blocker nazal spray in combination with inhaled corticosteroid on allergic asthma.Methods Sixty-one patients with moderate to severe allergic asthma were received either azelastine nazal spray(group A) or beclomethasone nazal spray(group B) or combination with azelastine nazal spray and beclomethasone nazal spray(group C) on the basis of inhaled samelterol/fluticasone for 3 months.Symptom scores of asthma and eosinophils in induced sputum were recorded,eosinophilic cationic protein(ECP),ICAM-1and interleukin 13(IL-13) in induced sputum supernatants were measured before and after the treatment.Results After treatment,there was significant improvement in symptom score,eosinophils in induced sputum and induced sputum ECP,ICAM-1 level in all three groups as compared with before the treatment(P 0.05);there was no significant difference in symptom score,induced sputum eosinophils and induced sputum ECP,ICAM-1 level between group A and group B(P 0.05);there was much better improvement in symptom score and induced sputum ECP in group C as compared with group A(P 0.05).However,there was no significant change in induced sputum IL-13 levels after treatment in all groups(P 0.05).Conclusion On the basis of inhaled corticosteroid,azelastine nazal spray significantly improves asthma symptom and reduces induced sputum ECP,ICAM-1 level and eosinophils in patients with asthma and allergic rhinitis." @default.
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- W2362104933 date "2012-01-01" @default.
- W2362104933 modified "2023-09-25" @default.
- W2362104933 title "Effect of H_1 blocker nazal spray and inhaled corticosteroids on eosinophils and inflammatory cytokines level in induced sputum in allergic asthma" @default.
- W2362104933 hasPublicationYear "2012" @default.
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