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- W2362109675 abstract "Objective To observe the effect of metformin on myocardial fibrosis in diabetic rats.Methods Male SD rats were randomly divided into 3 groups: the normal control group(NC group),the diabetes group(DM group),and the diabetes with metformin treatment group(MET group).After SD rats were fed a high-fat diet for four weeks,low-doses of streptozotocin(STZ) were intraperitoneally injected to establish the model of diabetes.Then,the DM group and MET group rats were fed the high-fat diet and metformin(ig,500 mg/(kg·d)) was given to the MET group for another 6 weeks.After the last administration,the ratio of heart to body weight(HW / BW) was measured,while myocardial collagen content was quantified through Masson-staining and expressions of TGF-β1 and TSP-1 were detected by immunohistochemical staining.Results Compared with the NC group,the HW / BW and myocardial collagen contents were significantly increased in the DM group and MET group(P0.05),while expressions of TGF-β1 and TSP-1 were also markedly increased in both groups(P0.05).Compared with the DM group,the HW / BW,myocardial collagen contents and expressions of TGF-β1 and TSP-1 were significantly reduced in the MET group.Conclusion Metformin shows the effect of anti-myocardium fibrosis in diabetic rats." @default.
- W2362109675 created "2016-06-24" @default.
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- W2362109675 date "2011-01-01" @default.
- W2362109675 modified "2023-09-27" @default.
- W2362109675 title "Effect of metformin on myocardial fibrosis in diabetic rats" @default.
- W2362109675 hasPublicationYear "2011" @default.
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