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- W2362111738 abstract "Objective To probe into the relationship between apoptosis and invasion/metastasis in patients with gastric carcinomas.?Methods 41 fresh gastric carcinomatous and adjacent non-neoplastic tissue specimens of 1.0 cm 3 were collected and each of them was cut into 3 portions. One was processed to produce single-cell suspension to assess the early apoptotic index (EAI) by using AV/PI bivariate FCM. The second portion was smashed to measure the activity of PAI-1 (a pointer of metastasis). The third was sectioned and examined for the expression of Bcl-2 oncoprotein by means of SABC immunohistochemical technique.?Results EAI varied markedly with Lauren classification (18.2±3.5% for diffuse type vs 11.4±3.7% for intestinal type, P 0.001) and with presence/absence of lymph node metastasis (14.2±3.9% vs 20.7±3.5%, P 0.001). The mean scoring of Bcl-2 was significantly higher in intestinal type than in diffuse type, whereas no difference was founded in respect to lymph metastasis (59% vs 33%, P 0.05). PAI-1 activity varied significantly with tissue type (0.76±0.12 vs 0.54±0.12 Au/ml, P 0.01) and with lymph metastasis (0.71±0.18 vs 0.52±0.18 Au/ml, P 0.05).?Conclusion EAI and the expression of Bcl-2 oncoprotein are the pointers of early apoptosis in gastric carcinomas. Both played important roles in the differentiation of tissue and in the startup of metastasis. But no direct relationship has been identified between apoptosis and PAI-1, the pointer of metastasis." @default.
- W2362111738 created "2016-06-24" @default.
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- W2362111738 date "2002-01-01" @default.
- W2362111738 modified "2023-09-26" @default.
- W2362111738 title "Study on the relation of early apoptosis to Bcl-2 protein expression and PAI-1 activity in patients with gastric carcinoma" @default.
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