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- W2362118133 abstract "Objective To investigate the effect of Detoxicating Medicine,Meridians-relieving Medicine and Engender Fluid Medicine on AQP5 in rats with Sjogren syndrome.Methods Seventy female SD rats were randomly divided into Detoxicating,Meridians-relieving and Engender Fluid group(A),Detoxicating group(B),Meridians-relieving group(C),Engender Fluid group(D),Prednisone group(E),physiological saline group(F) and normal control group(G).The rats were made into the model of Sjogren syndrome except the rats in normal control group which were injected the same dose physiological saline.Detoxicating,Meridians-relieving and Engender Fluid Medicine,Heat-clearing and Detoxicating Medicine,Blood-activating and Meridians-relieving Medicine,Yin-tonifying and Engender Fluid Medicine,Prednisone and physiological saline were given to each group for 28 days.Nothing was given to the normal control group.The drinking changes of rats were observed,and the changes of AQP5 in submandibular gland using semiquantitative analysis of RT-PCR.Results The drinking of rats in Detoxicating,Meridians-relieving and Engender Fluid group were reduced significantly than that of the other groups(P 0.05).The expression of AQP5 in Detoxicating,Meridians-relieving and Engender Fluid group were more significance than that of the other groups through the method of RT-PCR(P 0.05).The expression of AQP5 in the Engender Fluid group and Prednisone group were more significance than that of Detoxicating group and Meridians-relieving group(P 0.05).Conclusion Combination of Engender Fluid Medicine,Detoxicating Medicine and Meridians-relieving Medicine can ameliorate xerostomia in rats with SS by increasing the expression of AQP5 in the submandibular gland." @default.
- W2362118133 created "2016-06-24" @default.
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- W2362118133 date "2012-01-01" @default.
- W2362118133 modified "2023-09-23" @default.
- W2362118133 title "Analysis of the expression of AQP5 in rats with Sjogren syndrome intervened by Detoxicating Medicine,Meridians-relieving Medicine and Engender Fluid Medicine" @default.
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