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- W2362134611 abstract "Objective:To investigate the expression of myelin basic protein (MBP) on grafted olfactory ensheathing cells (OECs) and the activation of microglia in rat brain of experimental autoimmune encephalomyelitis (EAE) rat brain.Methods:Inbred strain OECs were labled with fluorescent marker CFSE following by injection of the cells into lateral ventricle of the Wistar rats suffering from EAE.The animals were then sacrificed on day 7 post-injection and their brains were assessed for the presence of the MBP+CFSE+ and ED1+CFSE+ cells in brain slices by immunohistology.Results:OECs did not express MBP molecules in culture,but they substantially migrated to several compartments of CNS when grafted in EAE brains and upgraded MBP.The ED1 positive cells,while rare in normal rats,were widely distributed in inflamed CNS and further increased after OEC injection,and some of the cells were shown CFSE positive.Conclusion:OECs may express MBP protein under inflamed condition and the autoantigen may be captured by microglia in EAE brain." @default.
- W2362134611 created "2016-06-24" @default.
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- W2362134611 date "2010-01-01" @default.
- W2362134611 modified "2023-09-25" @default.
- W2362134611 title "The expression of myelin basic protein on grafted olfactory ensheathing cells and activation of microglia in experimental autoimmune encephalomyelitis rat brain" @default.
- W2362134611 hasPublicationYear "2010" @default.
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