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- W2362150282 abstract "Objective To study the effects of orphanin FQ(OFQ) on the development of acute morphine tolerance(AMT). Methods Wistar rats were given 5 consecutive subcutaneous injections of morphine hydrochloric acid (6mg/kg) to establish AMT rat model. The pain threshold (PT) was determined by hot water induced tail flick test and the expression of OFQ mRNA was measured by RT PCR. Results PT was significantly increased 1 h after 5 consecutive s.c MOR in rats, which were treated by i.c.v OFQ receptor antisense oligo deoxynucleotides (ODNs) in advance .The expression of OFQ mRNA was increased 1 h after 5 consecutive injections. Conclusion The increase of OFQ may be an important reason in the development of AMT." @default.
- W2362150282 created "2016-06-24" @default.
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- W2362150282 date "2002-01-01" @default.
- W2362150282 modified "2023-09-25" @default.
- W2362150282 title "Effects of orphanin FQ on the development of acute morphine tolerance in rats" @default.
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