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- W2362159736 abstract "Objective:To study the inhibitory effect of 5-FU and thymopentin injection on hepatocellular cancer(HCC),and investigate the mechanism mediating its bioactivity.Methods: H22 tumor-bearing ICR mice were treated with normal saline(NS),5-FU(10mg/kg),thymopentin injection(0.2mg/kg),5-FU+thymopentin injection(10mg/kg+0.2mg/kg)for 5 days.Tumor volume and tumor weight,percentages of CD3+,CD4+,CD8+ and NK cells in peripheral blood,the number of WBC and LY,and serum levels of IL-2 and TNF-α were evaluated.Results: 5-FU and thymopentin injection produced a potent anti-tumor effect(P0.01).Mice treated with 5-FU and thymopentin injection had higher percentage of CD3+,CD4+ and NK cells(P0.05)in the peripheral blood than treated with NS.Mice receiving 5-FU and thymopentin injection had the higher number of WBC and LY(P0.05),and serum levels of IL-2 and TNF-α(P0.01).Conclusion: 5-FU and thymopentin injection can inhibit HCC growth by regulating immune function." @default.
- W2362159736 created "2016-06-24" @default.
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- W2362159736 date "2011-01-01" @default.
- W2362159736 modified "2023-09-23" @default.
- W2362159736 title "5-FU combined with thymopentin injection inhibit growth of hepatocellular cancer by regulating immune fuction" @default.
- W2362159736 hasPublicationYear "2011" @default.
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