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- W2362172 abstract "This chapter presents perspectives on receptor autoradiography in human brain. Autoradiography combines biochemistry and microscopic anatomy. Earlier, brains were dissected, tissues were homogenized, and receptors were measured in biochemical binding assays. The anatomical resolution was limited by the size of the piece of tissue that could be dissected and practically assayed. Receptor maps are beneficial as the receptors can be localized to small brain regions and, therefore, to specific neuronal pathways with a greater accuracy and precision that helps to explain the action of drugs in the brain. A key feature of technical approach is that the labeling of receptors in tissue sections is sectioned and thaw-mounted onto microscope slides. The in vitro labeling approach is advantageous because it is significantly cheaper as it is possible to label individual sections on slides that make more efficient use of tissues and radioactive compounds. Positron emission tomography (PET) scanning provides receptor maps without excision of tissue." @default.
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- W2362172 date "1991-01-01" @default.
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- W2362172 title "Perspectives on Receptor Autoradiography in Human Brain" @default.
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