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- W2362173732 abstract "Objective:The therapeutical effect of Rougan Xiaozhi decoction(RXD) in rats with fatty liver disease was studied.Method:The rat model with fatty liver disease was established by feeding high fat diet for 6 weeks.Then the rats were randomly divided into 6 groups:RXD groups(high dose,middle dose,low dose),Xuezhikang group,model group and control group.Four weeks later,Liver pathologic changes were observed together with the activity of serum alanine transaminase(ALT),aspartale transaminase(AST),the blood lipid,and the content of liver free fatty acids(FFA),total cholesterol(TG),low-density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),superoxide dismutase(SOD),malonaldehyde(MDA),nitric oxide(NO).Result:Compared with the natural model group,the level of ALT[(20.38±7.04),(29.74±6.77)U · L-1,P0.05],AST[(118.37±5.14),(167.43±15.67)U · L-1,P0.05],FFA[(453.12±81.36),(1 447.62±205.85)μmol · L-1,P0.05],TG[(0.47±0.42),(1.85±1.46)mmol · L-1,P0.01];LDL-C[(0.33±0.08),(0.44±0.05) mmol·L-1,P0.05],HDL-C[(1.03±0.18),(0.78±0.16) mmol·L-1,P0.05] mmol·L-1,SOD[(38.72±1.15),(30.81±4.52)U · mg-1,P0.05],MDA[(2.76±0.25),(6.51±2.66)nmol · mg-1,P0.01],NO[(32.27±2.65),(83.54±6.21)μmol · L-1,P0.01],further more it shows dose-effect relation,the effect of high dose group was correspond with Xuezhikang group;the hepatic steatosis degree were lighten obviously(P0.01).Conclusion:RXD has a good effect on fatty liver disease.This may lie in decreasing blood lipid and prevention of lipid peroxidation." @default.
- W2362173732 created "2016-06-24" @default.
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- W2362173732 date "2012-01-01" @default.
- W2362173732 modified "2023-09-28" @default.
- W2362173732 title "Effect of Rougan Xiaozhi Decoction on Liver Lipid Metabolism in Rats with Non-alcoholic Fatty Liver" @default.
- W2362173732 hasPublicationYear "2012" @default.
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