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- W2362183716 abstract "To compare the effect of CPU 86017 and berberine o n intracellular calcium mobilization and calcium entry by suppression on isolate d vascular smooth muscle (VSM)contraction. CPU-86917, berberine and bepridil we re applied to suppress three kinds of vascular contractions: (1)In the K-H sol ution, rat aortic rings were contracted (phase I contraction) after adding 100 mm ol·L{-1} KCl, (2)In Ca{2+}-free K-H solution, and (3) by adding 2.5 mmol·L{-1} CaCl-2. In K-H solution with normal Ca{2+}, contractions induced by high K+ can be suppressed by CPU-86017 at 30, 100, 300 mmol· L -1 in a dose-dependent manner, while berberine was less effective. In Ca {2+}-free K-H solution, CPU-86017 was more potent to suppress VSM contr action at low concentrations than berberine. After adding Ca2+ into the Ca{2+}-free K-H solution, CPU-86017 suppressed VSM contractions in a do se-dependent manner; whereas berberine exerted no significant inhibition until 300mol·L-1. Berberine showed a moderate inhibition on VSM contraction by suppressing intracellular release of calcium and calcium entry. CPU-86017 is potentiated with its suppression mainly on calcium entry compared with its sta rting material berberine." @default.
- W2362183716 created "2016-06-24" @default.
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- W2362183716 date "2000-01-01" @default.
- W2362183716 modified "2023-09-23" @default.
- W2362183716 title "Comparison of Inhibitory Activity of Berberine Derivative CPU 86017 and Berberine on Vascular Contractions" @default.
- W2362183716 hasPublicationYear "2000" @default.
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