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- W2362186479 abstract "Objective To evaluate the clinical value of proton magnetic resonance spectroscopy(1H-MRS) in clinically isolated syndrome(CIS).Methods MRI and 1H-MRS were performed in 6 patients with CIS and 5 healthy volunteers.NAA,Cr,Cho,and Lac peaks and the ratio of NAA/Cr,NAA/Cho and Cho/Cr were measured in the lesions,NAWM,and normal control group.Results Compared with normal control group,decreased NAA,Cr,Cho,mI peaks were demonstrated among lesions and NAWM in CIS,and increased Lac peaks were demonstrated among them,and Lip peaks were not changed.The ratios of NAA/Cr in lesions and NAWM(respectively:1.50±0.17,1.67±0.15) from CIS patients were significantly decreased than that of control group(1.82±0.08,P0.01).The ratio of NAA/Cho in lesions(1.40±0.28) was also significantly decreased than that of both NAWM(1.79±0.16) and control group(2.10±0.25,P0.001);Cho/Cr in lesions(1.09±0.14) was significantly increased than that in NAWM(0.93±0.02) and that in the control group(0.83±0.11,P0.001).mI/Cr in both lesions and NAWM was not more significant than that in control group.Conclusion 1H-MRS can reflect the metabolic abnormalities within the lesions and can detect the early biochemical changes in NAWM from CIS patients.1H-MRS has an important value in neurologic impairment,evaluation of therapeutic efficacy and prognosis." @default.
- W2362186479 created "2016-06-24" @default.
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- W2362186479 date "2012-01-01" @default.
- W2362186479 modified "2023-09-23" @default.
- W2362186479 title "Clinical application of magnetic resonance spectroscopy in clinically isolated syndrome" @default.
- W2362186479 hasPublicationYear "2012" @default.
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