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- W2362190681 abstract "Objective To observe changes of CX3CR1 protein expression in spinal dorsal horn of morphine tolerant rats with bone cancer pain,so as to explore the role of spinal CX3CR1 in the process of morphine tolerance in the rats,as well as interaction between CX3CR1 and microglia.Methods Forty-eight female adult Sprague-Dawley rats were randomly divided into four groups(n=12):control(C)group,sham operation(S)group,bone cancer pain-morphine tolerance(BM)group and BM+minocycline(BM+m)group.The rats in S group received sham operation of tibia.In BM group tibial cancer pain models were established by intra-tibia inoculation of Walker 256 mammary gland carcinoma cells,and 9 days later the rats were intrathecally administered morphine 20 μg/kg twice daily for 7 days.The rats in BM+m group were intrathecally administered minocycline 250 μg/kg for three days following the same treatment in BM group.The mechanical withdrawal threshold(MWT)and mechanical withdrawal duration(MWD)of all the rats were respectively measured pre-operation and at post-operative day(POD)3,6,9,12,15,18.The rats were killed at POD 18 and the expression of CX3CR1 protein and OX-42 in spinal lumber 4-6 tissues was respectively detected by using Western blot and immunohistochemistry methods.Results Stable morphine tolerance models were established in BM group at 7th day after intrathecal administration of morphine.The MWT was lower,and MWD was higher in BM group than those in C group and S group(all P0.01).There was statistically significant difference in MWT and MWD between BM group and BM+m group at POD 18(all P0.05).The expression of CX3CR1 protein and OX-42 in BM group was obviously higher than that in C group and S group(all P0.01)after morphine tolerance formed.The expression of CX3CR1 protein and OX-42 in BM+m group was significantly decreased after intrathecal administration of minocycline(all P0.05).Conclusion Spinal CX3CR1 may play an important role in the development of morphine tolerance in rats with bone cancer pain,and its expression is elevated by activating microglia." @default.
- W2362190681 created "2016-06-24" @default.
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- W2362190681 date "2011-01-01" @default.
- W2362190681 modified "2023-09-23" @default.
- W2362190681 title "Role of Spinal CX_3CR_1 in Process of Morphine Tolerance in Rats with Bone Cancer Pain" @default.
- W2362190681 hasPublicationYear "2011" @default.
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