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- W2362200844 abstract "OBJECTIVE:To investigate the effects of several chemotherapeutic drugs on telomer of human liver cancer BEL-7404 cells. METHODS: By MTT assay, telomerase repeat amplification protocol (TRAP), RT-PCR, Southern Blot and immuno-fluorescence, the changes of telomer of human liver cancer cell line BEL-7404 were detected, after being given cisplatin, vincristine, doxorubicin, mitomycin C at different concentrations and over different periods. RESULTS: The higher concentration and longer period of drugs were given, the stronger inhibition of telomerase activity, down regulation of hTERT and shortening of telomer would appeared. Cisplatin and mitomycin C showed the strongest activity. Cisplatin and mitomycin C of the high concentration group inhibited activity of telomere completely after 48 and 72 hours separately (activity=0.18±0.14, t= 85.42,P=0.000; activity=0.15±0.02,t=15.2,P=0.004), while no complete inhibition was seen in other groups. Vincristine of moderate and low concentration group showed no significant effect on shortening telomer (t=3.883, P=0.06; t=4.171, P= 0.053),while the rest groups revealed obvious effects. CONCLUSION: Chemotherapeutic drugs can suppress telomer of human liver cancer BEL-7404 cell, which correlates with category, concentration and period of drug." @default.
- W2362200844 created "2016-06-24" @default.
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- W2362200844 date "2006-01-01" @default.
- W2362200844 modified "2023-09-25" @default.
- W2362200844 title "Effects of chemotherapeutic drugs on telomer of human liver cancer BEL-7404 cell" @default.
- W2362200844 hasPublicationYear "2006" @default.
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