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- W2362205513 abstract "Objective To evaluate the expression of multidrug resistance-related markers in renal pelvic and ureteral carcinoma. Methods The immunohistochemical expression of P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), lung-resistance protein (LRP) and glutathione S-transferase Pi (GST-π) were examined in 51 patients with renal pelvic or ureteral carcinoma.The correlation between the expression and some clinicopathological parameters was analyzed. Results The positive expression rate of P-gp、MRP、LRP and GST-π in renal pelvic or ureteral carcinoma was 35.3%(18/51),39.2%(20/51),58.8%(30/51) and 43.1%(22/51) respectively.The rate of P-gp positive staining was increased with the advance of tumor grade (P0.05),whereas the rate of MRP and LRP decreased (P 0.05).Expression of MRP was significantly associated with that of GST-π (P=0.001,r=0.459). Conclusions The positive expression rate of LRP was the highest and suggests that LRP may play a major role in the intrinsic drug resistance in renal pelvic and ureteral carcinoma.LRP and MRP may be the most important multidrug resistance-related markers in the high grade tumors,while P-gp may be the major one in the low grade tumors. The correlation of MRP and GST-π indicates that there should be a common mechanism regulating their expression." @default.
- W2362205513 created "2016-06-24" @default.
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- W2362205513 date "2003-01-01" @default.
- W2362205513 modified "2023-09-28" @default.
- W2362205513 title "Expression of multidrug resistance-related markers in renal pelvic and ureteral carcinoma" @default.
- W2362205513 hasPublicationYear "2003" @default.
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