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- W2362244592 abstract "Objective To discuss the relationship between interleukin-1α(IL-1α),interleukin-1β(IL-1β) gene polymorphisms and cerebral infarction.Methods IL-1α-889C/T,IL-1β+3953C/T,IL-1β-511C/T gene polymorphisms in 110 patients with cerebral infarction(cerebral infarction group) and 110 healthy individuals(control group) were analyzed with polymerase chain reaction restriction and fragment length polymorphism(PCR-RFLP).Results There were significant differences in the distribution frequencies of IL-1α-889C/T and IL-1β+3953C/T genotypic genes in the cerebral infarction group as compared with the control group(P=0.035,P=0.023);the allele frequencies of IL-1α-889 T and IL-1β+3953 T in the cerebral infarction group were 13.2% and 5.9%,respectively,and there were significant differences as compared with 5.9% and 1.8% in the control group(P=0.009,P=0.026).There was no significant difference between the genotype distribution frequencies of IL-1β-511C/T and the allele frequencies in both groups(P=0.891,P=0.634).Conclusions IL-1α-889C/T and IL-1β+3953C/T gene polymorphisms are associated with cerebral infarction and the probability of IL-1β(-511C/T) and IL-1β+3953 T allelic genes may increase in patients with cerebral infarction." @default.
- W2362244592 created "2016-06-24" @default.
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- W2362244592 date "2006-01-01" @default.
- W2362244592 modified "2023-09-27" @default.
- W2362244592 title "The relationship between interleukin-10 gene polymorphisms and cerebral infarction" @default.
- W2362244592 hasPublicationYear "2006" @default.
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