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- W2362246293 abstract "Objective:To observe the therapeutic effect of decoction of guizhishaoyao-zhimu(GSZ) on immunologic arthritis and investigate the mechanism of this drug on the disease by determining the expression of serum TNF-α and RANKL in synovial tissues of joint.Methods:Some experimental animals were prepared for immunologic arthritis models induced by Freund′s complete adjuvant(FCA).Different doses of decoction of GSZ(GSZ 20.6 g/kg,10.3g/kg)were administrated in rat models.The serum of experimental animals were detected for TNF-α,and the counter-lateral synovial tissues of the knee joint were taken for observing pathological changes and the expression of RANKL.Results: In a 4-week of administration of guizhi-shaoyao-zhimu(GSZ),increased weight gain of the model rats was observed with lessened swelling of the joints(P0.05 or P0.01),which resulted in a lower serum TNF-α in the model rats(P0.01);The RANKL expression in synovial tissues tended to decrease(P0.01).Moreover,the findings suggest that GSZ 20.6g/kg can be favorable with respect to MTX in treatment of immunologic arthritis.Conclusion: Decoction of GSZ can treat the joint impairment of immunologic arthritis rats and the therapeutic mechanism may be relevant to reducing the content of TNF-α and inhibiting the expression of RANKL." @default.
- W2362246293 created "2016-06-24" @default.
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- W2362246293 date "2008-01-01" @default.
- W2362246293 modified "2023-09-24" @default.
- W2362246293 title "Effect of GSZ decoction on TNF-α and RANKL expression in immunologic arthritis rats" @default.
- W2362246293 hasPublicationYear "2008" @default.
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