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• W2362251387 abstract "Objective To investigate the expression levels and clinical significance of TNF-α and TGF-β in women with unknown aetiology recurrent spontaneous abortion( RSA). Methods 60 women with unknown aetiology RSA admitted to our hospital during January 2011 and June 2013 were chosen as unknown aetiology RSA group and 70 normal pregnant women of artificial abortion admitted to our hospital during January 2011 and June 2013 were chosen as normal pregnant group. Enzyme-linked immunosorbent assay( ELISA) was used to evaluate the protein levels of TNF-α and TGF-β in peripheral blood of unknown aetiology RSA group and normal pregnant group. The protein levels of TNF-α and TGF-β in villous and decidual tissues of unknown aetiology RSA group and normal pregnant group were tested using immunohistochemistry staining. Results ELISA result showed that the level of TNF-α in peripheral blood of unknown aetiology RSA group was increased significantly as compared with that of normal pregnant group [( 213. 69 ± 4. 17) ng / ml vs.( 135. 14 ± 5. 38) ng / ml,P 0. 05],whereas the level of TGF-β in peripheral blood of unknown aetiology RSA group was significantly lower than that of normal pregnant group [( 240. 32 ± 3. 27) ng / ml vs.( 403. 05 ±6. 71) ng / ml,P 0. 05]. Immunohistochemistry staining result showed that the TNF-α protein was expressed in villous issues of the two groups,and decidual cells of the two groups showed negative expression of TNF-α,the expression of TNF-α in villous tissues of unknown aetiology RSA group was significantly higher than that in normal pregnant group( P 0. 05); TGF-β expression in the two groups were villus syncytiotrophoblast cells,the expression of TGF-β in villous tissues of unknown aetiology RSA group was significantly lower than that in normal pregnant group( P 0. 05); Decidual tissues of two groups showed weak positive expression of TGF-β,the expression of TGF-β in decidual tissues of RSA group was lower than that in normal pregnant group,however,there was no statistically significant difference between the two groups( P 0. 05). Conclusion The increase of expression of TNF-α and the expression of TGF-β in peripheral blood and decidual tissues may be involved in the pathogenesis of unknown aetiology RSA." @default.
• W2362251387 created "2016-06-24" @default.
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• W2362251387 date "2015-01-01" @default.
• W2362251387 modified "2023-09-25" @default.
• W2362251387 title "Expressions of TNF-α and TGF-β in Women with Unknown Aetiology Recurrent Spontaneous Abortion and its Clinical Significance" @default.
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