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• W2362256523 abstract "Objective:To observe the effect on the expression of Bax and Bcl-2 of neurons in hippocampal CA1 region of neonatal rat with HIBD,Shenfu injection was used to treat HIBD.Methods:The experiment included two parts,one was to observe the effect on the physical development and survival rate,the other was to investigate the expression of Bax and Bcl-2 of neurons in left hippocampal CA1 region..Models of postnatal 7-day Sprague Dawley(SD)rats with HIBD were established.The neonatal rat with HIBD were equally divided into 4 groups:sham operation(S),control group(C),Shenfu injection pretreatment(P),and Shenfu injection treatment(SF).The increasing body weight of rats in every group was observed at 3,7,14 and 28 d after HI insult,and the survival rate of rats in every group on 28 d after HI insult.Similarly,four groups were established,however they were further divided into several subgroups again according to the time point 2 h before and 2,12,24 h,3,7,14 and 28 d after HI insult(n=6).After treatment with Shenfu injection,the expression of Bax and Bcl-2 in left hippocampal CA1 region at different time was investigated.The expression of Bax and Bcl-2 was performed by immunohistochemistry.Results:The increase of body weight in group C at 3,7,14 and 28 d after HI insult were significantly less than those of group S(P0.01)and also were group P and SF(P0.01,P0.05).The increase of body weight in group P at 3,7,14 and 28 d after HI insult were significantly higher than those of group C(P0.01,P0.05),and the increase of body weight in group SF at 7,14 and 28 d after HI insult were significantly higher than those of group C(P0.05).The survival rate of group C(60%)was significantly less than that of other groups(P0.05),and there was no obvious difference in survival rates between other groups(P0.05).The increasing expression of Bax and Bcl-2 in hippocampal CA1 region in group C were observed at 2 h after insult,and at 12 h after insult,compared to group S,the expression of Bax or Bcl-2 in group P was markedly lower or higher than that of group C(P0.01).The degree of expression were reached the peak at 1 d after insult,and the expression of Bax or Bcl-2 in group P was still markedly lower or higher than that of group C(P0.01).At 3 d after HI the expression of Bax and Bcl-2 was gradually decreasing,but the expression of Bax or Bcl-2 in group P and SF was markedly lower or higher than that of group C(P0.01).At 7 d after HI,the expression of Bax and Bcl-2 was decreased markedly,but the expression of Bax or Bcl-2 in group C was markedly higher or lower than that of group P and group SF(P0.01).Conclusion:Shenfu injection could enhance the physical development and elevate the survival rate in neonatal rats with HI insult.It significantly prevents apoptosis of hippocampus neurons from HI insult by down-regulation of the pro-apoptotic gene Bax,otherwise,and up-regulation of the anti-apoptotic gene Bcl-2." @default.
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• W2362256523 date "2008-01-01" @default.
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• W2362256523 title "Effects of Shenfu injection on the expression of Bax and Bcl-2 in the hippocampus neurons of neonatal rat with hypoxic-ischemic brain damage" @default.
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