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- W2362257029 abstract "Objective To investigate the expression of the integrin α6β4 in experimental allergic neuritis (EAN) and the realationship of the integrin α6β4 with functional states of Schwann cells (Sc) as well as the injury and repair of the myelin during EAN. Methods EAN was induced in Lewis rats and sciatic nerves were resected in 18 EAN and 3 normal rats. The expression of tissue integrin α6β4 was analyzed during the course of EAN induction and in controls by in situ hybridizaton and semi-quantitative RT-PCR. Results The detection of integrin α6 and β4 subunit by hybridizaton in situ demonstrated that expression of α6 subunit present no significant changes during the course of EAN, while expression of β4 declined in the early phase, showing less positive signals than those of the control, and restored its expression in the later or recovery phase. The changes of expression of integrin α6 and β4 in EAN were confirmed by semi-quanititative PT-PCR, using GAPDH as the internal standard. Conclusions The degeneration and injury of Sc caused by inflammation affect the expression of integrin, which shows similar changes in Sc during embryogenesis, indicating α6β4 may be a marker of Sc differatiation and at least an important molecule to mark the course of EAN. The expression of α6β4 correlate with the injury and repair of myelin during EAN." @default.
- W2362257029 created "2016-06-24" @default.
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- W2362257029 date "2003-01-01" @default.
- W2362257029 modified "2023-09-26" @default.
- W2362257029 title "Expression and significance of integrin a6β4 in experimental allergic neuritis" @default.
- W2362257029 hasPublicationYear "2003" @default.
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