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- W2362258536 abstract "Aim To evaluate the protective efficiency by immunized mice or rats with the synthesized peptide p14 or the mixture of the recombinant antigens LDH-Sj23 and SjFABP.Methods Peptide p14 which had been reported to be a T cell and B cell epitope of schistosme was synthesized,coupled with OVA,and then used to immunize Kunming mice and BALB/c mice.The mixture of recombinant antigen LHD-Sj23 and SjFABP was employed to vaccinate Wistar rats.The protective efficiency induced by these molecules was observed.Results and Conclusion 22.22%~30.18%(P0.05~0.001) worm reduction were obtained from the peptide p14 vaccinated mice.32.14% and 31.85% worm reduction were got respectively from Wistar rat vaccinated with recombinant antigen LHD-Sj23 or SjFABP (P0.05),and 47.28% worm reduction was obtained when the rats were injected with the mixture of these two recombinant antigen.The studies of the epitope and the ‘cocktail vaccine’ provides a basis for developing a higher protective vaccine against Schistosomiasis." @default.
- W2362258536 created "2016-06-24" @default.
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- W2362258536 date "2003-01-01" @default.
- W2362258536 modified "2023-09-23" @default.
- W2362258536 title "Epitope and ‘cocktail’ vaccine of 23kD antigen of Schistosoma japonicum" @default.
- W2362258536 hasPublicationYear "2003" @default.
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