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- W2362258984 abstract "Objective To assess the influence of blockade of costimulation on Th1/Th2 Cytokines shift in unexplained early recurrent spontaneous abortion (URSA). Methods The levels of IL-2, IFN-γ and IL-4 were determined by ELISA in the supernatant of cultured maternal peripheral blood mononuclear cells(PBMC) from 30 patients of URSA. Cytokine synthesis was induced by activation with antigens from a choriocarcinomer cell line of JEG-3, with CTLA4Ig at concentrations of 10 μg/mL and 1 μg/mL (experiment groups), or with IgG at the same concentrations (control groups). Results The CTLA4Ig groups showed significantly higher levels of Th2 cytokines IL-4 (P0.05), lower levels of Th1 cytokines IL-2 (P0.05) and the same levels of IFN-γ(P0.05), compared with the control groups of the same concentrations respectively. The same results were found between the experiment groups of different concentration. Conclusion CTLA4Ig could switch T cell responses from Th1 to Th2 in URSA by blockade of CD80/CD86 costimulation." @default.
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- W2362258984 date "2006-01-01" @default.
- W2362258984 modified "2023-10-11" @default.
- W2362258984 title "Influence of Blockade of Costimulation on Th1/Th2 Cytokines Shift in Unexplained Early Recurrent Spontaneous Abortion in vitro" @default.
- W2362258984 hasPublicationYear "2006" @default.
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