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- W2362259908 abstract "【Objective】To study the survive of leukemic cells and the effect of shRNA-3 targeting bcl-2 gene on the drug-sensitivity of primary leukemic cell to Daunorubicin(DNR).【Method】shRNA-3,which is leading se-quence selected by previous experiments,was transferred into leukemic cell.Six hours later,the cells were cultured with DNR.The growth of leukemic cell was detected by Trypan blue dye exclusion test at 24,48,72 hours respec-tively.The level of bcl-2 protein and P-gP was determined by immunochemistry.【Results】shRNA-3 could signifi-cantly decline the survive of leukemic cells from acute leukemic,the co-cultrue of shRNA-3 with DNR was the most effective,in 72 hours,cell numbers from 2.0×105/mL down to 0.8×105/mL,and downregulate the expression of bcl-2 and P-gP oncogenes,bcl-2 protein lowing rate from(47.21±7.26)% to(27.82±8.25)%(P 0.05),and P-gP lowing rate from(24.28±5.60)% to(16.34±4.15)%(P 0.05),as compared with alone of DNR.【Conclusion】The ef-fective shRNA-3 targeting bcl-2 can enhance the sensitivity of primary leukemic cell to DNR." @default.
- W2362259908 created "2016-06-24" @default.
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- W2362259908 date "2009-01-01" @default.
- W2362259908 modified "2023-09-25" @default.
- W2362259908 title "Study of bcl-2 shRNA enhances the drug-sensitivity of primary leukemic cell to Daunorubicin" @default.
- W2362259908 hasPublicationYear "2009" @default.
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