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- W2362272493 abstract "Objective:To observe the effect of FZY on withdrawal symptoms,NO concentration and NOS activity in blood serum of morphine-dependent rat.Methods:14 days morphine-dependent rat model was induced by administration(sc) of morphine at a gradual increasing dosage.The withdrawal symptoms hastened by naloxone were recorded.NO concentration and NOS activity in blood serum was tested by spectrophotometry.Results:①The score of withdrawal symptoms was reduced remarkably by FZY(5.48 g/kg and 10.96 g/kg),and weight lose was controlled by FZY at the dosage of 10.96 g/kg;②High levels of NO and NOS in blood serum were reduced by FZY at the dosage of 5.48 g/kg and 10.96 g/kg with dose-relativity.Conclusion:FZY has effect on relieving withdrawal symptoms of morphine-dependent rat with the possible mechanism of down regulation the level of NO by inhibiting NOS activity in vivo." @default.
- W2362272493 created "2016-06-24" @default.
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- W2362272493 date "2007-01-01" @default.
- W2362272493 modified "2023-09-23" @default.
- W2362272493 title "Effect of FZY on NO and NOS in blood serum of morphine-dependent rat" @default.
- W2362272493 hasPublicationYear "2007" @default.
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