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- W2362275215 abstract "In vitro,the inhibitory effects of total alkaloids from Clivia miniata Regel(TACMR) on proliferation of NCI-H446,SGC-7901,MCF-7,and SMMC-7721 were measured by MTT colorimetric assay.The inhibitory effects of TACMR on H22hepatic cancer was observed in mice with subcutaneous inoculation on the tumor cells and its effect on immunological function of mice bearing tumor by observing the influence to spleen index,thymus index and so on.In vitro,the results of MTT showed that TACMR inhibited proliferation of NCI-H446,SGC-7901,MCF-7,SMMC-7721 and a good dose-effect relationship and the IC50 values on them were 38.55,12.08,8.85 and 7.04 μg/mL.In vivo,TACMR has significant inhibitory effect on H22 tumor cells.The inhibition ratio was 35.2% with the dosage of 34 mg/kg,compared with the positive control group,spleen index increased significantly(P0.01).The inhibition ratio was 3.7% with the dosage of 136 mg/kg,compared with negative control group,thymus index and spleen index decreased significantly(P0.01),compared with the positive control group,thymus index decreased significantly(P0.01).In tumor inhibitory test,it was shown that TACMR has strong inhibition on tumor cells and certain impact on immunological function." @default.
- W2362275215 created "2016-06-24" @default.
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- W2362275215 date "2011-01-01" @default.
- W2362275215 modified "2023-09-25" @default.
- W2362275215 title "Anti-Tumor Effect of Total Alkaloids from Clivia miniata" @default.
- W2362275215 hasPublicationYear "2011" @default.
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