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- W2362276088 abstract "OBJECTIVE: To evaluate the releasing characteristics of domestic and original sodium valproate sustained-release tablet in vitro.METHODS: The drug releasing rates of the tablests were determined according to dissolution method Ⅱ of the Chinese Pharmacopoeia and potentiometry.The parameters of the releasing rate(T50,Td,and m) were obtained by the weibull disposition and excel.Analysis of variance of the parameters were statistically evaluated by q-test.RESULTS: There were significant differences between the domestic and original sodium valproate sustained-release tablets in T50 and Td(P 0.01),but the slope rate m had no statistical difference(P0.05),nor in release parameters.CONCLUSIONS: There was no difference in accumulative releasing amount between domestic and original sodium valproate sustained-release tablets in study period,but the domestic tablets showed higher release velocity at the initial release period.The two tablets were both stable in technology,but different in quality." @default.
- W2362276088 created "2016-06-24" @default.
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- W2362276088 date "2009-01-01" @default.
- W2362276088 modified "2023-09-24" @default.
- W2362276088 title "Domestic and Original Sodium Valproate Sustained-release Tablet in Releasing Rate in Vitro" @default.
- W2362276088 hasPublicationYear "2009" @default.
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