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- W2362281526 abstract "Objective:To investigate the function of costimulatory factor B7-H1 in antigen-specific immune response.Methods:The effect of B7-H1 in soluble antigen(PPD)-induced lymphocyte proliferation was detected by using anti-B7-H1 neutralizing antibody.Then,B7-H1-transfected ECV304 cell line and mock-transfected control were used to stimulate PPD-induced lymphocytes,respectively,which were examined for proliferation,cytokines secretion,cytokine mRNA level and changes of T cell subsets.The function of T cell stimulated with the B7-H1-transfected ECV304 cell line was also inspected through auto-or allo-lymphocyte adoptive transfering assay.Results:Antigen-specific lymphocyte proliferation and cytokine secretion were inhibited by anti-B7-H1 neutralizing antibody.Compared with mock-transfected control,the B7-H1-transfected ECV304 cells enhanced the proliferation of PPD-stimulated lymphocytes,promoted the secretion of IL-10 and expression of its mRNA.Besides,the ratio of T cell subsets was also changed owing to the enlargement of CD4+T cell populations.In adoptive transfering assay,lymphocytes stimulated with the B7-H1-transfected ECV304 cells markedly inhibited auto-or allo-lymphocytes proliferation.Conclusion:Costimulatory factor B7-H1 could enhance antigen-specific lymphocytes proliferation and induce some T cell subset with immunosuppressive activity." @default.
- W2362281526 created "2016-06-24" @default.
- W2362281526 creator A5022526821 @default.
- W2362281526 date "2007-01-01" @default.
- W2362281526 modified "2023-09-26" @default.
- W2362281526 title "B7-H1 enhances Ag-specific lymphocytes proliferation and induces immunosuppressive T cells" @default.
- W2362281526 hasPublicationYear "2007" @default.
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