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- W2362291298 abstract "Objective To evaluate the effect of external stents on preventing anastomotic intimal hyperplasia and medial thickening with non-restrictive macro-porous polyester stent around porcine vein grafts with end-to-side anastomoses.Methods Studies were performed using white race pigs(n=10) weight 25～30kg.All the animals underwent bilateral saphenous vein into carotid artery bypass grafting.The end of a segment of reversed saphenous vein was beveled to about 45 degree and then anastomosed to the carotid artery by an end-to-side anastomotic technique.In each animal,a macroporous stent was placed around a graft on one side and an unstented graft on the opposite side as control.The polyester stent was long enough to cover both anastomoses completely.The size of the stent allowed unrestricted expansion of the graft in initial response to arterial pressure,and the stent did not oppress the anastomosis.After 35 days of surgery,10 animals were taken to remove grafts.Anastomosis dimensions were measured on histological sections.Results All the grafts were patent when they were removed.35 days after surgery,stents significantly reduced proximal anastomotic neointimal thickening [(0.698 1±0.085 9)mm vs(0.376 0±0.064 5)mm,P0.01)] and medial thickening [(0.827 5±0.127 0)mm vs(0.640 4±0.058 8)mm,P0.01)].Stents also significantly reduced distal anastomotic neointimal thickening [(0.619 7±0.145 8)mm vs(0.413 0±0.097 2)mm,P0.01)] and medial thickening [(0.822 4±0.136 3)mm vs(0.578 6±0.146 4)mm,P0.01)].Conclusion External non-restrictive polyester stent can inhibit anastomosis(end-to-side anastomoses) neointimal formation and medial thickening,and prevent late vein grafts restenosis." @default.
- W2362291298 created "2016-06-24" @default.
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- W2362291298 date "2008-01-01" @default.
- W2362291298 modified "2023-09-25" @default.
- W2362291298 title "Experimental study of external stents preventing stenosis of porcine saphenous vein grafts′ anastomosis" @default.
- W2362291298 hasPublicationYear "2008" @default.
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