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- W2362293238 abstract "Objective:To investigate the relationships between gene associated with retinoid-interferon-induced mortality-19(GRIM-19),signal transducers and activators of transcription 3(STAT3) and clinical pathological characteristics of osteosarcoma,and their correlations in osteosarcoma by observing the expression of GRIM-19 and STAT3 in osteosarcoma. Methods:SP immunohistochemical staining was used to detect the expression of GRIM-19 and STAT3in 35 cases osteosarcoma and 14 cases osteochondroma. Results:The positive expression rate of STAT3 in osteosarcoma was obviously higher than that in osteochondroma,while the positive expression rate of GRIM-19 was obviously lower in osteosarcoma compared with osteochondroma(P 0.01). In osteosarcoma,the expression of STAT3 was associated with Enneking stage and pulmonary metastasis; the expression of GRIM-19 was associated with Enneking stage(P 0.05). In osteosarcoma,the expression of STAT3 was negatively correlated with expression of GRIM-19(P 0.05). Conclusions:High expression of STAT3 and low expression of GRIM-19 coexist in osteosarcoma,which play important role in development of osteosarcoma." @default.
- W2362293238 created "2016-06-24" @default.
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- W2362293238 date "2013-01-01" @default.
- W2362293238 modified "2023-09-23" @default.
- W2362293238 title "EXPRESSION AND SIGNIFICANCE OF GRIM-19 AND STAT3 IN OSTEOSARCOMA" @default.
- W2362293238 hasPublicationYear "2013" @default.
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