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• W2362296504 abstract "AbstractAIM To assess the role of endogenous opioid peptides in experimental cirrhosis and ascites formation in rats.METHODS Leucine enkephalin (L-ENK), β-endorphine (β-EP) and dynorphine A1-13 (DynA1-13) were measured by using radioimmunoassay in carefully collected plasma samples from 20 healthy rats and 37 cirrhosic (17 with ascites) rats induced by carbon tetrachloride and phenobarbital.RESULTS Plasma LENK increased markedly in two groups of cirrhosis rats compared with these of healthy controls (P0.01,P0.01,respectively). The increase in plasma LENK was proportional to the degrees of liver damage as judged in the experimental cirrhotis in rats with or without ascites, and both were the positively correlated with prothrombin time (PT) (r=0.68, P0.01; r=0.69, P0.01) and negatively correlated with plasma albumin (r=-069,P001; r=-056,P001). DynA1-13 was also significantly higher than those of healthy controls (P0.01, P0.01, respectively). And it was positively correlated with PT (r=0.65,P0.01; r=0.67,P0.01)and inversely correlated with plasma albumin (r=-0.64,P0.01; r=-0.59,P0.01). In addition, althongh LENK was directly correlated with DynA1-13 in the two groups of cirrhosis r=0.61,P0.01; r=0.76,P0.01), there was no significant difference of βEP.CONCLUSION The increase in plasma L-ENK and DynA1-13, mainly caused by diminished hepatic inactivation, can attribute ascites formation in experimental cirrhosis in rats. The liver may play an important role in the elimination of low molecular opioid peptides such as L-ENK and DynA1-13, but not the high molealar peptides such as β-EP." @default.
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• W2362296504 date "1998-01-01" @default.
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• W2362296504 title "Role of endogenous opioid peptides in experimental cirrhosis and ascites formation in rats" @default.
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