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- W2362317146 abstract "Background and purpose:MAD2 is one of the mitotic checkpoints and it is closely associated with tumors.Our aim was to study the expression of gene MAD2 and tumor suppressor gene in colorectal cancer and to demonstrate the relationship between the expression of gene MAD2 and tumor suppressor gene in colorectal cancer,adenoma and normal tissue and to evaluate their clinical significance.Methods:Immunohistochemistry method and real-time fluorescence quantitative PCR were used to analyze the expression of gene MAD2 in colorectal cancer,adenoma and normal tissue.PCR amplifi cation and DNA sequencing were performed to detect the mutations of gene MAD2.p53,p27,p21 and p16 were determined in colorectal cancer and normal tissue by immunohistochemistry methods.Results:The expression of MAD2 in colorectal cancer was obviously higher than in adenoma and normal tissue(66.7% vs 39.6% vs 22.9%) ,there were signifi cant differences among colorectal cancers,adenoma and normal tissue(P0.001) ,and it was also related to tumor differentiation and survival time(P0.05) .No mutation of gene MAD2 was found in colorectal cancer.There was a high relationship between positive expression of MAD2,p53,p27,p21 and p16(P0.05) .Conclusion:Our data indicated that positive expressions of MAD2 and tumor suppressor gene were involved mainly in colorectal carcinogenesis and MAD2 was strongly associated with the prognosis of colorectal cancer." @default.
- W2362317146 created "2016-06-24" @default.
- W2362317146 creator A5082669026 @default.
- W2362317146 date "2009-01-01" @default.
- W2362317146 modified "2023-09-22" @default.
- W2362317146 title "Expression of MAD2 and tumor suppressor gene in the colorectal cancer and clinical significance" @default.
- W2362317146 hasPublicationYear "2009" @default.
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