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- W2362332912 abstract "Objective:To investigate the effect of the water extract from Picris japoncia Thunb on blood glucose in normal mice and diabetic model mice.Method: Diabetic model in mice was induced by caudal vein injection of 50 mg·kg-1 alloxan.Mice were randomly divided into 6 groups: control group,model group,Xiaokewan pill group(0.75 g·kg-1·d-1),low dose,moderate dose and high dose groupsof P.japoncia(1.5,3,6 g·kg-1·d-1).The drugs were administrated to mice for 14 days.Determination of fasting blood glucose by blood sampling,in the corresponding time,and acute toxicity experiment were carried out.Result: The blood glucose value of low dose,moderate dose and high dose group of P.japoncia achieved respectively was(7.52±1.47),(7.33±2.99),(7.79±1.84) mmol·L-1 after administrated for 14 days,there were significant difference in blood glucose value compared with model group.The acute toxicity experiment revealed that the maximum dose of intragastric administration was 120 g·kg-1.Conclusion: The total extracts of P.japoncia had obvious hypoglycemic activity and little toxicity in hyperglycemia model mice." @default.
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- W2362332912 date "2012-01-01" @default.
- W2362332912 modified "2023-09-23" @default.
- W2362332912 title "Study on Hypoglycemic by Picris japoncia" @default.
- W2362332912 hasPublicationYear "2012" @default.
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