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- W2362347883 abstract "Objective: To investigate the best consequence of combined treatment with herceptin and docetaxel to the breast cancer in vitro and its mechanism. Methods: Inhibition ratio to human breast cancer cells (MDA-MB543) of the group of herceptin treatment ,chemical treatment with docetaxel and herceptin-chemical combined treatment were assayed by the method of MTT and change of cell cycle by flow cytometry (FCM). Results: Combined treatment of herceptin with docetaxel 18h later had got the largest inhibition ratio to breast cancer cells (53.12%) and docetaxel got its largest inhibition ratio to cells(46.15%) . It was higher than group of docetaxel (41.55%) and the groups of combined treatment with other consequences ( P0.01) .And in this sequence, the cells were apparently arrested in G0/G1 and G2/M phase. Conclusion: Combined treatment of herceptin with docetaxel 18h later had the strongest toxicity to breast cancer cells and herceptin enhanced the toxicity of docetaxel to breast cancer cells best .And this sequence could apparently arrested cells in G0/G1 and G2/M phase ,then induce apoptosis." @default.
- W2362347883 created "2016-06-24" @default.
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- W2362347883 date "2007-01-01" @default.
- W2362347883 modified "2023-09-23" @default.
- W2362347883 title "Inhibitory effect of combined herceptin and docetaxel in different sequence on human breast cancer cells in vitro" @default.
- W2362347883 hasPublicationYear "2007" @default.
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