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- W2362351541 abstract "The effects of furyl-dihydropyridine I(FDP I)on the contractile response of electrically paced guinea pig heart muscles in vitro were studied.FDP I and nifedipine(Nif)produced concentration-dependent negative inotropic action in guinea pig papillary muscles; the IC50 was 1.62 and 0.42μmol·L-1,respectively.FDP 12.0μmol·L-1 decreased the post-rest contraction and developed tention evoked by paired stimulation in the left atrium.The drug also had a frequency-dependent negative inotropic effect.Action potential was investigated with a glass microelectrode in guinea pig papillary muscles and itwas found that FDP I 1.0 and 4.0μmol·L-1 brought about the decrease of APD30,APD50 and APD90 but it had no effect on action potential amplitude and Vmax.It is concluded that the negative inotropic effect of FDP I results not only from the reduction of calcium influx through the cell membrane,but also from the inhibition of calcium translocation in the sarcoplasmic reticulum." @default.
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- W2362351541 title "Effects of furyl-dihydropyridine I on contraction and action potential of guinea pig heart muscles" @default.
- W2362351541 hasPublicationYear "1993" @default.
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