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- W2362359369 abstract "Objective To study the effect of Nattokinase on the thrombus formation in the thrombus model, the change of blood pressure, the size of thrombus and the activity of plasminogen activator inhibitor(PAI) or tissue plasminogen activator(tPA) were measured.Methods Before making thrombus model by coating the abdomial aorta with filter paper soaked in 30% FeCl 3, S-D rats were divided into five groups randomly, fed with Nattokinase or Lumbrukinaseor normal chow respectively for two days. The femoral artery pressures were traced by Powerlab/4s .The protein contents of the thrombus were determined by Bradford method. The PAI and tPA activity were detected by ELISA. Results The decreased level of femoral artery pressure of the rats fed with Nattokinase or Lumbrukinase were lower (-11.62±7.36%、-8.37±10.29%、-7.28±4.54%)than that of the rats fed with normal chow (-59.97±12.29%, P 0.01). The wet weight, dry weight or the protein content of the thrombus were significantly lower on the rats fed with Natto than that on the rats fed with normal chow ( P 0.01). The tPA activity increased while the PAI/tPA ratio decreased significantly in plasma of the rats fed with Nattokinase or Lumbrukinase, compared with that in plasma of the rats fed with normal chow( P 0.01). Conclusion Nattokinase can inhibit the formation of thrombus and promote the fibrinolysis acitivity in plasma." @default.
- W2362359369 created "2016-06-24" @default.
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- W2362359369 date "2003-01-01" @default.
- W2362359369 modified "2023-09-25" @default.
- W2362359369 title "The effect of Nattokinase on the thrombosis formation of abdominal aorta in rat" @default.
- W2362359369 hasPublicationYear "2003" @default.
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