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- W2362364861 abstract "Objective To investigate the effects of pyrrolidine dithiocarbamate (PDTC) on plasma concentrations of proinflammatory cytokines and myocardial energy metabolism induced by cardiopulmonary bypass (CPB) .Methods Twelve healthy mongrel dogs of both sexes weighing 13.5-17.5 kg were randomly divided into 2 groups (n = 6 in each group) : PDTC group and control group. The animals were anesthetized with intraperitoneal 2.5% pentobarbital sodium 25 mg·kg-1, intubated and mechanically ventilated. In PDTC group PDTC 30 mg·kg-1 was given i.v. after tracheal intubation while in control group normal saline was given instead of PDTC. Aorta was clamped for 60 min and then undamped for 60 min reperfusion during CPB. Blood samples were taken before (baseline), 30 and 60 min after aortic clamping and 30 and 60 min after aortic unclamping for determination of plasma concentrations of TNF-α and IL-1β. Myocardial tissue was obtained before and 60 min after aortic clamping and 60 min after aortic unclamping for determination of myocardial content of adenine nucleotide (ATP, ADP, AMP, TAN, EC) and expression of ICAM-1 protein.Results Plasma TNF-α concentration was increased after aortic cross-clamping as compared to the baseline value before clamping in both groups but the TNF-α concentration was significantly lower in PDTC group than in control group (P 0.01) . Plasma IL-1β concentration increased significantly after aortic cross-clamping as compared to the baseline value in control group whereas no significant increase in IL-1β concentration was found in PDTC group. The expression of ICAM-1 in myocardium was significantly increased after aortic cross-clamping in both groups but was significantly lower in PDTC group than in control group (P 0.05). The myocardial content of ATP was decreased after aortic cross-clamping as compared to the baseline value in both groups. The recovery of ATP content was significantly better in PDTC group than in control group. Similar changes in myocardial TAN and EC content were also found.Conclusion Pretreatment with PDTC is effective in reducing CPB-induced inflammatory response and changes in myocardial energy metabolism." @default.
- W2362364861 created "2016-06-24" @default.
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- W2362364861 date "2005-01-01" @default.
- W2362364861 modified "2023-09-23" @default.
- W2362364861 title "Effects of pyrrolidine dithiocarbamate on inflammatory response and myocardial energy metabolism in dogs during cardiopulmonary bypass" @default.
- W2362364861 hasPublicationYear "2005" @default.
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