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- W2362383522 abstract "Objective: Our aim was to investigate the relationship between the product of metastatic suppressor gene KAI1/CD82 and the clinical pathology of primary non small cell lung cancer (NSCLC). Methods: The S P immunohistochemistry was used to detect the expression of KAI1/CD82 in cancer and normal cells of 61 cases of NSCLC and metastatic tissue in 23 cases. Results: Strong expression was observed in normal alveolar and bronchial squamous epithelium, while expression decreased in cancer cell.The rate of positive expression was 31.15% (19/61), of decreased expression 24.59%(15/61), of no expression 44.26%(27/61). Uneven expression was noted in tumor cell membrane, usually in granular shape. Positive expression rate of primary focus in metastasis group was 7.14%, remarkable lower than that of non metastasis group (51.52%, P=0 0004). There was tendency of decreased expression of KAI1 in metastatic foci of 23 cases, compared with the corresponding primary foci. Significant difference was found between the primary and secondary foci concerning the non expression rate of KAI1/CD82 (P=0 0230). Conclusion:The decreased expression of KAI1/CD82 may be associated with the metastasis of NSCLC, and could be used as a marker for predicting the potential metastasis of cancer." @default.
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- W2362383522 date "2003-01-01" @default.
- W2362383522 modified "2023-09-26" @default.
- W2362383522 title "Relationship Between Expression of KAI1/CD82 Gene in Non-Small Cell Lung Cancer and Metastasis" @default.
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