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- W2362394876 abstract "Objective To explore the effects of proliferation and apoptosis of fibroblast-like synoviocyte on articular inflammation in adjuvant arthritis(AA). Methods 0.1 mL of the complete Freud's adjuvant (CFA) was subcutaneously injected into the tail of Wistar rat. 14 days after CFA injection,Arthritis index (AI) was evaluated every 7 days and a group of rats (6 rats) were executed every 7 days. Fibroblast-like synoviocyte was cultured in vitro. The amount of apoptotic cells and cells in S-phase was measured by flow cytometry. The correlation of fibroblast-like synoviocyte apoptosis and AI was analyzed. Results AI was increased in the early course of AA,but decreased in the later course. Flow cytometry demonstrated the amount of cells in S-phase increased with the course of AA progressed. The increase of S-phase cells positively correlatedto the increase of RI. Apoptosis of fibroblast-like synoviocyte in the early course of AA was significantly inhibited,but the inhibition attenuated in the later course. Apoptosis inhibition was positively correlated to the increase of AI. Conclusion In the pathogenesis of AA,the inhibition of fibroblast-like synoviocyte apoptosis may take a role in acute synovial inflammtion." @default.
- W2362394876 created "2016-06-24" @default.
- W2362394876 creator A5061211243 @default.
- W2362394876 date "2008-01-01" @default.
- W2362394876 modified "2023-09-26" @default.
- W2362394876 title "A Clinical Research on Treating Old Patients with Chronic Obstructive Pulmonary Disease by Combined Inhaling Treatment" @default.
- W2362394876 hasPublicationYear "2008" @default.
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