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- W2362406265 abstract "Objective To decide whether the extracellular signal-regulated kinase (ERK) play a crucial role in PC12 differentiation induced by nerve-growth factor (NGF). Methods Cells were treated with NGF, and cell extracts were subjected to immunobblotting with antibodies against ERK1/2 and pp-ERK1/2. To more clearly define the role of ERK1/2, a small molecule inhibitor of MAPK/ERK kinase named U0126 was examined for its effect on the cellular action of NGF in PC12 cells. Results We showed that NGF induced sustained activation of ERK1/2 in 1 h. In the presence of U0126, however, NGF-induced differentiation were no longer observed and the expression of pp-ERK1/2 was severely impaired. Conclusion Our results indicated that sustained activation of ERK1/2 in the early stage of cell differentiation is necessary for NGF-induced neurite outgrowth, and the differentiation was markedly regulated by NGF treatment through activation of the ERK1/2 pathway. In a word, activation of ERK1/2 is essential to neuronal differentiation of PC12 cells." @default.
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- W2362406265 date "2005-01-01" @default.
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- W2362406265 title "Role of ERK in PC12 cells induced by differentiation NGF" @default.
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