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- W2362412964 abstract "AIM: To explore the possible mechanism underlying the up-regulation on gap junctional intercellular communication(GJIC) by all-transretinoic acid(ATRA) in human endometriotic stromal cells.METHODS: Ectopic endometrial stromal cells isolated from human endometriotic tissues were treated with 0.1,1 and 10 μmol/L ATRA for 24,48,72,96 and 120 h,respectively,and control groups were introduced simultaneously.Laser scanning confocal microscope was applied to determine the function of GJIC in these stromal cells.Cx43,Cx26 and Cx32,which are associated with GJIC,were investigated at the mRNA and protein levels.RESULTS: The ability of fluorescence recovery was enhanced significantly in endometriotic stromal cells exposed to 1 and 10 μmol/L ATRA.No evidence for fluorescence recovery was confirmed in endometriotic stromal cells treated with 0.1 μmol/L ATRA.Cx43,Cx26 and Cx32 were not detected at mRNA and protein levels in control groups.Treatment of endometriotic stromal cells with 1,10 μmol/L ATRA for 72 h induced the expressions of Cx43 mRNA and protein while lost the same effects on Cx26 and Cx32.The function of GJIC in endometriotic stromal cells was only associated with dephosphorylated Cx43 protein.CONCLUSION: ATRA induces selectively the expressions of Cx43 mRNA and dephosphorylated Cx43 protein in endometriotic stromal cells,and then GJIC in these cells are effectively up-regulated,which implys that ATRA may be a potential drug to administer the patients suffering from endometriosis." @default.
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- W2362412964 date "2008-01-01" @default.
- W2362412964 modified "2023-09-24" @default.
- W2362412964 title "Mechanism of up-regulation on gap junctional intercellular communication by all-trans retinoic acid in human endometriotic stromal cells in vitro" @default.
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